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CRBN ligand-76

Ligands for E3 Ligase

CRBN ligand-76 is a ligand for the CRBN E3 ubiquitin ligase, facilitating the development of PROTAC (Proteolysis Targeting Chimeras). This compound engages specifically with the CRBN E3 ligase, promoting ubiquitination and degradation of target proteins. Its application in targeted protein degradation offers potential for therapeutic intervention in various diseases, including cancer and neurodegenerative disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	3065251-82-0
Applications	Ligands for E3 Ligase
Formula	C₁₁H₈BrF₂NO₂
Molecular Weight	304.09
SMILES	BrC1=CC(F)=C(C2C(NC(CC2)=O)=O)C=C1F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.