Fig. 1 · Structure
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CRBN ligand-891
Ligand for E3 Ligase
CRBN ligand-891 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to conjugate a target protein ligand through a linker, enabling the development of PROTAC molecules for targeted protein degradation studies. Its application is particularly relevant in drug discovery and the investigation of cellular pathways involving protein homeostasis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2618349-23-6 |
| Applications | Ligand for E3 Ligase |
| Formula | C13H12N2O3 |
| Molecular Weight | 244.25 |
| SMILES | O=C1NC(=O)C(C2=COC=3C=CC(N)=CC32)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.