Fig. 1 · Structure
Documents & Downloads
CRBN ligand-9
CRBN Ligand
CRBN ligand-9 is a selective ligand targeting cereblon (CRBN) with a binding affinity (Ki) of 8.9 μM. This compound is designed for use in the synthesis of PROTACs (proteolysis targeting chimeras), facilitating the targeted degradation of specific proteins. CRBN ligand-9 serves as an essential tool for research in drug discovery and development, particularly in studies focused on targeted protein degradation mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 55003-81-1 |
| Applications | CRBN Ligand |
| Formula | C13H9N3O6 |
| Molecular Weight | 303.23 |
| SMILES | O=C1NC(CCC1N2C(C3=CC=C(C=C3C2=O)[N+](=O)[O-])=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.