Fig. 1 · Structure
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Crelosidenib
Cat. No.
A75788
CAS
2230263-60-0
IDH1 Inhibitor
Crelosidenib is a selective inhibitor targeting mutant isocitrate dehydrogenase 1 (IDH1), demonstrating potent activity with IC50 values of 6.27 nM for IDH1 R132H and 3.71 nM for IDH1 R132C. Additionally, it shows inhibitory effects on IDH2 mutants, with IC50s of 36.9 nM for IDH2 R140Q and 11.5 nM for IDH2 R172K. Crelosidenib is primarily employed in research focused on IDH1 and IDH2 mutations, particularly in the context of cancer therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2230263-60-0 |
| Applications | IDH1 Inhibitor |
| Formula | C28H36N6O3 |
| Molecular Weight | 504.62 |
| Synonyms | LY3410738; Mutant IDH1-IN-6 |
| SMILES | O=C1OCC2=CN=C(N[C@H](C3=CC=C([C@@H](N4CCN(C(C=C)=O)CC4)CC5CC5)C=C3)C)N=C2N1CC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.