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Crinecerfont tosylate

CRF1 Receptor Antagonist

Crinecerfont tosylate is a selective antagonist of the corticotropin-releasing factor receptor type-1 (CRF1). This compound effectively inhibits CRF1 receptor signaling, leading to a reduction in adrenocorticotropic hormone (ACTH) secretion. Its ability to enhance the sensitivity of the hypothalamic-pituitary-adrenal axis negative feedback makes it valuable in studies related to chronic stress and classic congenital adrenal hyperplasia caused by 21-hydroxylase deficiency. Additionally, Crinecerfont tosylate features an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, further expanding its utility in chemical biology research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	2649012-17-7
Applications	CRF1 Receptor Antagonist
Formula	C₃₄H₃₆ClFN₂O₄S₂
Molecular Weight	655.24
Synonyms	SSR-125543 tosylate
SMILES	C#CCN(C1=NC(C2=C(C=C(C(C)=C2)OC)Cl)=C(S1)C)[C@H](C3=CC(F)=C(C=C3)C)CC4CC4.O=S(C5=CC=C(C)C=C5)(O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.