Fig. 1 · Structure
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Crinecerfont
CRF1 Receptor Antagonist
Crinecerfont is a selective antagonist of the corticotropin-releasing factor receptor type-1 (CRF1). It effectively inhibits CRF1 receptor signaling, leading to a reduction in adrenocorticotropic hormone secretion and enhanced sensitivity of the hypothalamic-pituitary-adrenal axis negative feedback in models of chronic stress. This compound is valuable for research into chronic stress conditions and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Additionally, Crinecerfont serves as a click chemistry reagent, featuring an alkyne group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 752253-39-7 |
| Applications | CRF1 Receptor Antagonist |
| Formula | C27H28ClFN2OS |
| Molecular Weight | 483.04 |
| Synonyms | SSR-125543 |
| SMILES | C#CCN(C1=NC(C2=C(C=C(C(C)=C2)OC)Cl)=C(S1)C)[C@H](C3=CC(F)=C(C=C3)C)CC4CC4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.