Fig. 1 · Structure
Documents & Downloads
CRK12-IN-2
CRK12 Inhibitor
CRK12-IN-2 is a selective inhibitor of CRK12, demonstrating potent activity against Trypanosoma congolense and Trypanosoma vivax with EC50 values of 3.2 nM and 0.08 nM, respectively. This compound is integral for investigating the mechanisms underlying animal trypanosomiasis and serves as a valuable tool in the study of parasitic infections. The efficacy of CRK12-IN-2 positions it as a significant candidate for further research into therapeutic options targeting these pathogens.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1990479-17-8 |
| Applications | CRK12 Inhibitor |
| Formula | C23H33F2N5O3S2 |
| Molecular Weight | 529.67 |
| SMILES | CC(CS(=O)(N[C@H]1CC[C@@H](CC1)NC2=NC(N)=C(S2)C(C3=C(C=C(C=C3F)CN(C)C)F)=O)=O)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.