Fig. 1 · Structure
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Crozbaciclib fumarate
CDK4/6 Inhibitor
Crozbaciclib fumarate is a potent inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), with IC50 values of 3 nM and 1 nM, respectively. This compound effectively regulates cell cycle progression by hindering the phosphorylation of retinoblastoma protein, thereby halting proliferation in various cancer cell lines. Crozbaciclib fumarate is utilized in oncology research, particularly in studies investigating the therapeutic potential of targeting CDK4/6 in tumor growth and resistance mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2567494-39-5 |
| Applications | CDK4/6 Inhibitor |
| Formula | C32H34F2N6O4 |
| Molecular Weight | 604.65 |
| SMILES | CC(C1(CCCC1)C2=CC(C3=NC(NC4=CC=C(C5CCN(C)CC5)C=N4)=NC=C3F)=C6)=NC2=C6F.OC(/C=C/C(O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.