Fig. 1 · Structure
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CRT0066854 hydrochloride
PKC Inhibitor
CRT0066854 hydrochloride is a selective inhibitor of atypical protein kinases C (PKCs). It demonstrates potent inhibition against full-length PKCι, PKCζ, and ROCK-II kinases, with IC50 values of 132 nM, 639 nM, and 620 nM, respectively. This compound is valuable for research applications involving cell signaling, cancer biology, and the study of neurodegenerative diseases, providing insights into the role of PKCs in various biological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2250019-91-9 |
| Applications | PKC Inhibitor |
| Formula | C24H26ClN5S |
| Molecular Weight | 452.01 |
| SMILES | N[C@H](CNC1=NC(C2=CC=NC=C2)=NC3=C1C(CCCC4)=C4S3)CC5=CC=CC=C5.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.