Fig. 1 · Structure
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CRT0093964
AKR1C3 Inhibitor
CRT0093964 is a selective inhibitor of the aldehyde-ketone reductase 1C3 (AKR1C3) isoform, demonstrating an IC50 of 0.11 μM. This compound exhibits no inhibitory activity against other AKR isoforms (AKR1C1, AKR1C2, AKR1C4) or cyclooxygenase enzymes (COX-1, COX-2). CRT0093964 is valuable for research in leukemia, hormone-related cancers, and colon cancer, providing insights into the role of AKR1C3 in tumorigenesis and potential therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 700856-05-9 |
| Applications | AKR1C3 Inhibitor |
| Formula | C15H20ClN3O2 |
| Molecular Weight | 309.79 |
| SMILES | O=C(N1CCOCC1)N2CCN(C3=CC=C(Cl)C=C3)CC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.