Fig. 1 · Structure
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(-)-Cryptopleurine
TMV
(-)-Cryptopleurine is an alkaloid that primarily targets the inhibition of tobacco mosaic virus (TMV), demonstrating significant antiviral properties. In addition to its antiviral activity, it exhibits potent cytotoxic effects against various cancer cell lines, including A375 melanoma and MCF-7 breast cancer, with an IC50 of 3 nM. Furthermore, (-)-Cryptopleurine effectively reduces hypoxia-induced gene expression in a hypoxia response element (HRE) reporter assay, displaying an IC50 of 8.7 nM. This compound also inhibits protein synthesis in both yeast and mammalian ribosomes, indicating its potential utility in molecular biology research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 482-22-4 |
| Applications | TMV |
| Formula | C24H27NO3 |
| Molecular Weight | 377.48 |
| Synonyms | (R)-Cryptopleurine; NSC 19912 |
| SMILES | COC1=CC2=C3C=C(C(OC)=CC3=C4C[C@]5(CCCCN5CC4=C2C=C1)[H])OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.