Cryptotanshinone

Catalog No.: A10244

Stat3 inhibitor

Cryptotanshinone

Cryptotanshinone Chemical Structure

CAS NO. 35825-57-1

Cryptotanshinone, a natural compound isolated from the roots of Salvia miltiorrhiza Bunge (Danshen), dramatically blocks STAT3 Tyr705 phosphorylation but not STAT3 Ser727 phosphorylation in DU145 cells, and significantly inhibits JAK2 phosphorylation with IC50 of ~5 μM without affecting the phosphorylation of upstream kinases c-Src and EGFR.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $40.00

Special Price $36.00

25 mg

Regular Price: $90.00

Special Price $81.00

50 mg

Regular Price: $170.00

Special Price $153.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Cryptotanshinone, a natural compound isolated from the roots of Salvia miltiorrhiza Bunge (Danshen), dramatically blocks STAT3 Tyr705 phosphorylation but not STAT3 Ser727 phosphorylation in DU145 cells, and significantly inhibits JAK2 phosphorylation with IC50 of ~5 μM without affecting the phosphorylation of upstream kinases c-Src and EGFR.
Targets
STAT3 (HCT-116 cells)
4.6 μM
In vitro DMSO 5 mg/mL heating (16.87 mM)
Water <1 mg/mL (<1 mM)
Ethanol 1 mg/mL heating (3.37 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.74 mL 168.69 mL 337.38 mL
0.5 mM 6.75 mL 33.74 mL 67.48 mL
1 mM 3.37 mL 16.87 mL 33.74 mL
5 mM 0.67 mL 3.37 mL 6.75 mL

*The above data is based on the productmolecular weight 296.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A10244
Actions Inhibitor
M. Wt 296.4
Formula C19H20O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 35825-57-1
Synonyms Tanshinone
SMILES C[[email protected]]1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C

Product Tags

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy Cryptotanshinone | Cryptotanshinone Supplier | purchase Cryptotanshinone | Cryptotanshinone cost | Cryptotanshinone manufacturer | order Cryptotanshinone | Cryptotanshinone distributor | buy 35825-57-1| 35825-57-1 Supplier | purchase 35825-57-1 | 35825-57-1 cost | 35825-57-1 manufacturer | order 35825-57-1 | 35825-57-1 distributor
Rewards