Fig. 1 · Structure
Documents & Downloads
CSK-IN-1
CSK Inhibitor
CSK-IN-1 is a highly potent inhibitor of C-terminal Src kinase (CSK), exhibiting IC50 values below 3 nM in HTRF assays and 4 nM in Caliper assays. This compound enhances T cell proliferation in response to T cell receptor signaling, making it a valuable tool for research in immunology and T cell activation studies. Its oral bioavailability further supports its utility in in vivo research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2380027-49-4 |
| Applications | CSK Inhibitor |
| Formula | C34H32ClFN8O4 |
| Molecular Weight | 671.12 |
| SMILES | O=C(C1=NN(C2CCN(C(CC(C)(C#N)C)=O)CC2)C3=C1C=C(F)C=C3)NC4=CC=C(NC(C5=C6C=CC(OC)=CN6N=C5)=O)C(Cl)=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.