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CTX-439

CDK12/CDK13 Inhibitor

CTX-439 is a potent, orally active ATP-competitive inhibitor targeting CDK12 and CDK13, with an IC50 of 3.1 nM for CDK12 and 9.2 nM for CDK13. This small-molecule compound is effective in inducing DNA damage and apoptosis in tumor cells. CTX-439 is particularly relevant for research focused on breast and ovarian cancer therapies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2377487-13-1
Applications	CDK12/CDK13 Inhibitor
Formula	C₃₀H₃₂F₃N₉O₄S
Molecular Weight	671.69
SMILES	O=C(CCC)N(C1=CN=C(C2=CN=C(OC)N=C2)C=N1)[C@@H]3CC[C@@H](NC4=NC(C5=CC(S(C)(=O)=O)=CN=C5)=C(C(F)(F)F)C=N4)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.