Fig. 1 · Structure
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CU-76
cGAS Inhibitor
CU-76 is a selective inhibitor of human cyclic GMP-AMP synthase (hcGAS) with an IC50 of 0.24 μM. By targeting the cGAS enzyme, CU-76 effectively inhibits the DNA sensing pathway in human cells. This compound is particularly valuable for applications in autoimmune research, aiding in the understanding of immune responses and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2400954-58-5 |
| Applications | cGAS Inhibitor |
| Formula | C11H8F2IN5O2 |
| Molecular Weight | 407.11 |
| SMILES | O=C(C1=NC(N)=NC(NC2=CC(F)=C(I)C(F)=C2)=N1)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.