Fig. 1 · Structure
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CU239
RPE65 Inhibitor
CU239 is a potent competitive inhibitor of RPE65, with an IC50 value of 6 μM for the isomerization of 11-cis retinal. It demonstrates delayed chromophore regeneration following light exposure and provides partial protection to the retina against high-intensity light-induced damage. This reagent is valuable for research applications focusing on retinal degeneration and associated disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 946249-82-7 |
| Applications | RPE65 Inhibitor |
| Formula | C19H15F3N4O3S |
| Molecular Weight | 436.41 |
| SMILES | O=C(NC1=CC=C(OC(F)(F)F)C=C1)CC2=CSC(NC(NC3=CC=CC=C3)=O)=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.