CVARARTR is a potent antagonist of programmed cell death ligand-1 (PD-L1) with a dissociation constant (KD) of 281 nM. It promotes the internalization of PD-L1, leading to a decrease in its surface expression. This mechanism effectively restores cytokine secretion and enhances T cell proliferation in CT26 cells. Additionally, CVRARTR demonstrates antitumor efficacy in the CT26 homograft mouse model, making it a valuable tool for research in melanoma and immunotherapy studies.
CVARARTR is a potent antagonist of programmed cell death ligand-1 (PD-L1) with a dissociation constant (KD) of 281 nM. It promotes the internalization of PD-L1, leading to a decrease in its surface expression. This mechanism effectively restores cytokine secretion and enhances T cell proliferation in CT26 cells. Additionally, CVRARTR demonstrates antitumor efficacy in the CT26 homograft mouse model, making it a valuable tool for research in melanoma and immunotherapy studies.
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