Fig. 1 · Structure
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CVRARTR
PD-L1 Antagonist
CVARARTR is a potent antagonist of programmed cell death ligand-1 (PD-L1) with a dissociation constant (KD) of 281 nM. It promotes the internalization of PD-L1, leading to a decrease in its surface expression. This mechanism effectively restores cytokine secretion and enhances T cell proliferation in CT26 cells. Additionally, CVRARTR demonstrates antitumor efficacy in the CT26 homograft mouse model, making it a valuable tool for research in melanoma and immunotherapy studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 2349354-64-7 |
| Applications | PD-L1 Antagonist |
| Formula | C33H64N16O9S |
| Molecular Weight | 861.03 |
| SMILES | [C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)[C@@H](C)O)=O)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CS)N)=O)C(C)C)=O)CCCNC(=N)N)=O)C)=O)CCCNC(=N)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.