Fig. 1 · Structure
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CW-3308
PROTAC
CW-3308 is a potent PROTAC that selectively targets BRD9, facilitating targeted protein degradation. It exhibits significant potential in inhibiting synovial sarcoma, rhabdomyoma, and other BRD9-dependent pathologies. Composed of the BRD9 binding ligand Naphthyridin-Me-dimethoxybenzene-COOH, the linker 3-Azaspiro[5.5]undecane-9-methanol, and the E3 ubiquitin ligase ligand Thalidomide-methylpyrrolidine, CW-3308 offers a sophisticated approach for studying protein interactions and degradation pathways in cancer research and beyond.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3055592-99-6 |
| Applications | PROTAC |
| Formula | C45H48N6O8 |
| Molecular Weight | 800.90 |
| SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=C4C(CN(CC(CC5)CCC65CCN(C(C7=C(OC)C=C(C(C8=CC=NC=C98)=CN(CC)C9=O)C=C7OC)=O)CC6)C4)=C3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.