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Cyanostatin B

LAP Inhibitor

Cyanostatin B is a selective inhibitor of leucine aminopeptidase M (LAP), exhibiting an IC50 of 12 ng/mL. This cyanobacterial lipopeptide has been shown to possess weak inhibitory effects on protein phosphatase 2A (PP2A) and angiotensin-converting enzyme (ACE), with an IC50 of 130 μg/mL. In biological assays, Cyanostatin B demonstrates cytotoxic and genotoxic properties in human hepatocytes, inhibiting the proliferation of HepG2 cells and inducing DNA single-strand breaks, ultimately leading to genomic instability. Its impactful effects make it a valuable tool in cancer research and studies of genotoxic stress.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	850131-23-6
Applications	LAP Inhibitor
Formula	C₄₀H₅₉N₅O₉
Molecular Weight	753.92

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.