Fig. 1 · Structure
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Cyclic GMP sodium
Second Messenger
Cyclic GMP sodium serves as a pivotal second messenger, mediating intracellular signaling in response to extracellular cues such as nitric oxide and natriuretic peptides. Its biological activities are facilitated through interactions with cGMP-dependent protein kinases, cGMP-gated ion channels, and phosphodiesterases. This compound is known to inhibit platelet adhesion and aggregation, making it a valuable tool in research related to cardiovascular health. Additionally, cGAMP, a derivative of cyclic GMP and AMP, can promote IRF3 phosphorylation and nuclear translocation, thereby augmenting antiviral immune responses, highlighting its relevance in immunological studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 40732-48-7 |
| Applications | Second Messenger |
| Formula | C10H11N5NaO7P |
| Molecular Weight | 367.19 |
| SMILES | O[C@@H]([C@H](N1C=NC2=C1N=C(N)NC2=O)O[C@@H]3CO4)[C@@H]3OP4([O-])=O.[Na+] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.