Fig. 1 · Structure
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Cyclic GMP
Second Messenger
Cyclic GMP (cGMP) serves as a critical second messenger that mediates cellular responses to extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Its biological activity is primarily facilitated through cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and phosphodiesterases (PDEs). cGMP plays a role in inhibiting platelet adhesion and aggregation, making it significant in cardiovascular research. Furthermore, its derivative, cGAMP (Cyclic-GMP-AMP), has been shown to promote IRF3 phosphorylation and nuclear translocation, thereby enhancing antiviral immune responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 7665-99-8 |
| Applications | Second Messenger |
| Formula | C10H12N5O7P |
| Molecular Weight | 345.21 |
| SMILES | O[C@@H]([C@H](N1C=NC2=C1N=C(N)NC2=O)O[C@@H]3CO4)[C@@H]3OP4(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.