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Cyclin A/B RxL-IN-1

Cyclin A/B RxL Inhibitor

Cyclin A/B RxL-IN-1 is an inhibitor that targets the interaction between Cyclin A/B and the hydrophobic patch (HP). With an IC50 of 0.12 μM, it effectively inhibits Cyclin A, demonstrating notable antitumor activity in cell line-derived xenograft (CDX) models. This compound is valuable for research on E2F-driven cancers, including small-cell lung cancer (SCLC), providing insights into therapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3036231-62-3
Applications	Cyclin A/B RxL Inhibitor
Formula	C₄₆H₆₃Cl₂F₄N₇O₇
Molecular Weight	972.93
SMILES	CC(C[C@@H]1NC([C@H](CCCCNC(C(C)(NC([C@@H](N(C1=O)C)CC2=CC(Cl)=CC=C2Cl)=O)C)=O)N(C([C@H](C3CC3)NC([C@@H]4C[C@H](CN4C(C5(CC6(C5)CCC6)C(F)(F)F)=O)F)=O)=O)C)=O)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.