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Cyclin A/B RxL-IN-2

Cyclin A/B Inhibitor

Cyclin A/B RxL-IN-2 is a macrocyclic peptide that acts as a selective inhibitor of Cyclin A and Cyclin B. It exhibits high potency with an IC50 of 0.05 μM for Cyclin A and less than 0.02 μM for Cyclin B, alongside Kd values of 2.7 nM and 1.0 nM, respectively. This compound competes for binding at the hydrophobic patch of Cyclin A/B, disrupting interactions with the substrate RxL motif, leading to replication stress and DNA damage in E2F-high cells, as well as inducing mitotic catastrophe and apoptosis. Cyclin A/B RxL-IN-2 demonstrates efficacy in inhibiting tumor growth in NCI-H69 and NCI-H446 small cell lung cancer xenograft models, making it a valuable tool for research in small-cell lung cancer.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3064485-73-7
Applications	Cyclin A/B Inhibitor
Formula	C₄₅H₆₂ClF₆N₇O₇
Molecular Weight	962.46
SMILES	O=C([C@H]1N(C(C2(C(F)(F)F)CC(F)(F)C2)=O)C[C@H](F)C1)N[C@@H](C3CC3)C(N([C@@H]4C(N[C@@H](CC(C)C)C(N(C)[C@@H](CC5=CC(Cl)=CN=C5OC6CC6)C(N(C)CCCCCCC4)=O)=O)=O)C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.