Fig. 1 · Structure
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Cycloartenyl ferulate
Drug Derivative
Cycloartenyl ferulate is a derivative of γ-oryzanol, functioning primarily as an antioxidant and anti-inflammatory agent. It selectively binds to the IFNγR1 receptor with a binding affinity of Kd = 0.5 μM, thereby activating the JAK1/2-STAT1 signaling pathway. Cycloartenyl ferulate mitigates paraquat-induced apoptosis and reactive oxygen species (ROS) generation in HK2 cells while enhancing NK cell activation and cytolytic activity through upregulation of activation receptors and release of cytotoxic molecules, including IFNγ. This compound shows potential in cancer research and the intervention of allergic inflammation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 21238-33-5 |
| Applications | Drug Derivative |
| Formula | C40H58O4 |
| Molecular Weight | 602.89 |
| Synonyms | Cycloartenol ferulate; Cycloartenol ferulic acid ester |
| SMILES | C[C@]12[C@@]3([H])[C@@]4(CC[C@@]1([C@@](CC2)([H])[C@H](C)CC/C=C(C)\C)C)[C@@]5([C@](CC3)([H])C(C)([C@H](CC5)OC(/C=C/C6=CC(OC)=C(C=C6)O)=O)C)C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.