Fig. 1 · Structure
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Cyclocreatine
ATP Supplier, Creatine Analogue
Cyclocreatine is a creatine analogue that functions as an ATP supplier and bioenergetic protector. By providing elevated ATP levels, it suppresses metabolic pathways related to creatine, demonstrating potential cognitive enhancement and amelioration of the autistic and epileptic phenotypes in animal models of creatine transporter deficiency. Additionally, Cyclocreatine offers neuroprotective effects against ischemic injury and may facilitate cardiac recovery during reperfusion. It has demonstrated efficacy in reducing neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology, making it valuable for research into ischemic heart disease, Alzheimer’s disease, and microglial dysfunction-related neurodegenerative disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 35404-50-3 |
| Applications | ATP Supplier, Creatine Analogue |
| Formula | C5H9N3O2 |
| Molecular Weight | 143.15 |
| SMILES | O=C(O)CN1CCNC1=N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.