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Cyclotraxin B

Catalog No.: A34974
TrkB Inhibitor
Cyclotraxin B is a selective inhibitor of the TrkB receptor, effectively crossing the blood-brain barrier. It inhibits brain-derived neurotrophic factor (BDNF) induced TrkB activity in a non-competitive manner, with an IC50 of 0.30 nM. Cyclotraxin B exhibits notable analgesic and anxiolytic properties, making it a valuable tool for research into neurological disorders and pain management.
Cyclotraxin B 1203586-72-4 TrkB Inhibitor
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Size Price Stock Qty
1mg
$135.00
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5mg
$295.00
In stock
10mg
$495.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionCyclotraxin B is a selective inhibitor of the TrkB receptor, effectively crossing the blood-brain barrier. It inhibits brain-derived neurotrophic factor (BDNF) induced TrkB activity in a non-competitive manner, with an IC50 of 0.30 nM. Cyclotraxin B exhibits notable analgesic and anxiolytic properties, making it a valuable tool for research into neurological disorders and pain management.
Product Information
Catalog NumA34974
FormulaC48H73N13O17S3
Molecular Weight1200.37
CAS Number1203586-72-4
SequenceCys-Asn-Pro-Met-Gly-Tyr-Thr-Lys-Glu-Gly-Cys (Disulfide bridge:Cys1-Cys11)
Sequence shorteningCNPMGYTKEGC (Disulfide bridge:Cys1-Cys11)
SMILESO=C1N2[C@](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC3=CC=C(O)C=C3)C(=O)N[C@@]([C@@H](C)O)(C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@H](C(O)=O)CSSC[C@H](N)C(=O)N[C@H]1CC(N)=O)[H])(CCC2)[H]
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Protein Tyrosine Kinases > Trk Receptors