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Cys-Arg-Gly-Asp-Phe-Pro-Ala-Ser-Ser-Cys (Disulfide bridge: Cys1-Cys10)

αIIbβ3 Antagonist

Cys-Arg-Gly-Asp-Phe-Pro-Ala-Ser-Ser-Cys (Disulfide bridge: Cys1-Cys10) is a decapeptide that serves as an antagonist of the integrin αIIbβ3. It effectively inhibits platelet aggregation and the adhesion of proMMP-13, making it a valuable tool in research focused on hemostasis and extracellular matrix interactions. Its unique cyclic RGD motif enhances its specificity for integrin binding, supporting various studies in cardiovascular and cellular biology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	166184-23-2
Applications	αIIbβ3 Antagonist
Formula	C₄₁H₆₁N₁₃O₁₅S₂
Molecular Weight	1040.13
SMILES	[H][C@@]12CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC2=O)C(O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.