Fig. 1 · Structure
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Cystamine dihydrochloride
Tgase Inhibitor
Cystamine dihydrochloride is a potent inhibitor of transglutaminase (Tgase), which plays a critical role in protein crosslinking and cellular processes. Additionally, it demonstrates inhibitory activity against caspase-3, with an IC50 of 23.6 μM. This compound is valuable for researching neurodegenerative disorders, particularly Huntington's disease, and other pathological conditions where Tgase and apoptosis are implicated.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 56-17-7 |
| Applications | Tgase Inhibitor |
| Formula | C4H14Cl2N2S2 |
| Molecular Weight | 225.20 |
| SMILES | NCCSSCCN.[H]Cl.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.