Cilengitide

Catalog No.: A12372

Integrin inhibitor

Cilengitide

Cilengitide Chemical Structure

CAS NO. 188968-51-6

Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$180.00
25 mg
$320.00
50 mg
$550.00
10mM * 1mL in DMSO
$200.00
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  • Marion Bouvet, .et al. Anti-integrin αv therapy improves cardiac fibrosis after myocardial infarction by blunting cardiac PW1+ stromal cells, Sci Rep, 2020, 10: 11404 PMID: 32647159
  • Rosalie Richards, .et al. 4D imaging and analysis of multicellular tumour spheroid cell migration and invasion, bioRxiv, 2018, 15 Oct 2018
  • Hiroki Kanazawa, .et al. Canstatin inhibits hypoxia-induced apoptosis through activation of integrin/focal adhesion kinase/Akt signaling pathway in H9c2 cardiomyoblasts, PLoS One, 2017, 12(2): e0173051 PMID: 28235037
  • Yasuda J, .et al. T3 peptide, a fragment of tumstatin, stimulates proliferation and migration of cardiac fibroblasts through activation of Akt signaling pathway, Naunyn Schmiedebergs Arch Pharmacol, 2017, Nov;390(11):1135-1144 PMID: 28785775
  • Yasuda J, .et al. T3 peptide, an active fragment of tumstatin, inhibits H2O2-induced apoptosis in H9c2 cardiomyoblasts, Eur J Pharmacol, 2017, Jul 15;807:64-70 PMID: 28457922
  • Hsian-Yu Wang, .et al. Non-small-cell lung cancer cells combat epidermal growth factor receptor tyrosine kinase inhibition through immediate adhesion-related responses, Onco Targets Ther, 2016, 9: 2961-2973 PMID: 27284246

Biological Activity

Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.99 mL 84.94 mL 169.88 mL
0.5 mM 3.4 mL 16.99 mL 33.98 mL
1 mM 1.7 mL 8.49 mL 16.99 mL
5 mM 0.34 mL 1.7 mL 3.4 mL

*The above data is based on the productmolecular weight 588.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12372
Actions Inhibitor
CAS No. 188968-51-6
Formula C27H40N8O7
M. Wt 588.66
Purity >98%
Synonyms EMD 12197,EMD-85189,EMD-121974,NSC-707544,D03497
SMILES CC(C)[[email protected]]1C(=O)N[[email protected]](C(=O)NCC(=O)N[[email protected]](C(=O)N[[email protected]@H](C(=O)N1C)CC2=CC=CC=C2)CC(=O)O)CCCN=C(N)N
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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