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Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.
| In vitro (25°C) | DMSO | 100 mg/mL (169.87 mM) | |
| Water | 8 mg/mL (13.59 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.99 mL | 84.94 mL | 169.88 mL |
| 0.5 mM | 3.4 mL | 16.99 mL | 33.98 mL |
| 1 mM | 1.7 mL | 8.49 mL | 16.99 mL |
| 5 mM | 0.34 mL | 1.7 mL | 3.4 mL |
*The above data is based on the productmolecular weight 588.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12372 |
|---|---|
| Actions | No |
| M. Wt | 588.66 |
| Formula | C27H40N8O7 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 188968-51-6 |
| Synonyms | EMD 12197,EMD-85189,EMD-121974,NSC-707544,D03497 |
| SMILES | CC(C)[[email protected]]1C(=O)N[[email protected]](C(=O)NCC(=O)N[[email protected]](C(=O)N[[email protected]@H](C(=O)N1C)CC2=CC=CC=C2)CC(=O)O)CCCN=C(N)N |
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