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Biological Activity
CZC-25146 is a potent and selective LRRK2 inhibitor. CZC-25146 prevents mutant LRRK2-induced injury of cultured rodent and human neurons with mid-nanomolar potency.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.05 mL | 95.24 mL | 190.48 mL |
| 0.5 mM | 3.81 mL | 19.05 mL | 38.1 mL |
| 1 mM | 1.9 mL | 9.52 mL | 19.05 mL |
| 5 mM | 0.38 mL | 1.9 mL | 3.81 mL |
*The above data is based on the productmolecular weight 525.00. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13448 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1330003-04-7 |
| Formula | C22H25FN6O4S.HCl |
| M. Wt | 525.00 |
| Purity | >98% |
| Synonyms | CZC-25146, CZC 25146, CZC25146 |
| SMILES | COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)F.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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