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D-520

Dopamine D2/D3 Agonist

D-520 is a potent dopamine D2/D3 receptor agonist, demonstrating an EC50 of 4.73 nM and 2.18 nM for D2 and D3 receptors, respectively. This compound exhibits significant inhibitory effects on the formation of amyloid-beta (Aβ) aggregates and facilitates the disaggregation of both alpha-synuclein and Aβ aggregates in vitro. D-520 shows promising efficacy in animal models of Parkinson's disease, making it a valuable tool for research in Parkinson's disease and dementia associated with Parkinson’s disease.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	1619269-47-4
Applications	Dopamine D2/D3 Agonist
Formula	C₃₁H₃₉N₃O₃
Molecular Weight	501.66
SMILES	OC1=CC(C2=CC=C(N3CCN(CCN(CCC)[C@@H]4CC5=C(C(O)=CC=C5)CC4)CC3)C=C2)=CC=C1O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.