D-520 is a potent dopamine D2/D3 receptor agonist, demonstrating an EC50 of 4.73 nM and 2.18 nM for D2 and D3 receptors, respectively. This compound exhibits significant inhibitory effects on the formation of amyloid-beta (Aβ) aggregates and facilitates the disaggregation of both alpha-synuclein and Aβ aggregates in vitro. D-520 shows promising efficacy in animal models of Parkinson's disease, making it a valuable tool for research in Parkinson's disease and dementia associated with Parkinson’s disease.
D-520 is a potent dopamine D2/D3 receptor agonist, demonstrating an EC50 of 4.73 nM and 2.18 nM for D2 and D3 receptors, respectively. This compound exhibits significant inhibitory effects on the formation of amyloid-beta (Aβ) aggregates and facilitates the disaggregation of both alpha-synuclein and Aβ aggregates in vitro. D-520 shows promising efficacy in animal models of Parkinson's disease, making it a valuable tool for research in Parkinson's disease and dementia associated with Parkinson’s disease.
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