Fig. 1 · Structure
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D-α-Hydroxyglutaric acid
ROS Activator
D-α-Hydroxyglutaric acid (R-2-Hydroxyglutarate) primarily functions as a reactive oxygen species (ROS) activator and is notable for its role as a metabolite in D-2-hydroxyglutaric aciduria. It acts as a weak competitive antagonist of α-ketoglutarate (α-KG), demonstrating inhibition of α-KG-dependent dioxygenases with a Ki value of 10.87 mM. This compound is known to enhance ROS production and has been shown to bind to and inhibit ATP synthase, thereby influencing mTOR signaling pathways. Its unique properties make it applicable in various research settings focused on metabolic disorders and oxidative stress.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 13095-47-1 |
| Applications | ROS Activator |
| Formula | C5H8O5 |
| Molecular Weight | 148.11 |
| Synonyms | (R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid |
| SMILES | O=C(O)[C@H](O)CCC(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.