D-AP4 (D-2-Amino-4-phosphonobutyric acid) is a broad-spectrum NMDA receptor antagonist, functioning as a phosphono analogue of glutamate. This compound also acts as an agonist for a quisqualate-sensitized AP6 site in the hippocampus. D-AP4 effectively inhibits AMPA receptor-mediated 57Co2+ influx in cultured cerebellar granule cells, with an IC50 value of approximately 100 μM. This makes D-AP4 a valuable tool for investigating glutamatergic signaling and its implications in neurobiology and related research applications.
D-AP4 (D-2-Amino-4-phosphonobutyric acid) is a broad-spectrum NMDA receptor antagonist, functioning as a phosphono analogue of glutamate. This compound also acts as an agonist for a quisqualate-sensitized AP6 site in the hippocampus. D-AP4 effectively inhibits AMPA receptor-mediated 57Co2+ influx in cultured cerebellar granule cells, with an IC50 value of approximately 100 μM. This makes D-AP4 a valuable tool for investigating glutamatergic signaling and its implications in neurobiology and related research applications.
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