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D-Arg1,D-Trp5,7,9,Leu11-Substance P

Small Cell Lung Cancer Inhibitor

[D-Arg1,D-Trp5,7,9,Leu11]-Substance P is a neuropeptide antagonist targeting small cell lung cancer (SCLC) by inhibiting cell growth. It effectively blocks colony formation induced by various neuropeptides such as vasopressin and bradykinin. This compound attenuates calcium mobilization and mitogen-activated protein kinase activation triggered by these neuropeptides. Furthermore, [D-Arg1,D-Trp5,7,9,Leu11]-Substance P demonstrates efficacy in inhibiting H-69 xenograft tumor growth in nude mice, highlighting its potential for cancer research applications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor, Antagonist
CAS Number	122481-75-8
Applications	Small Cell Lung Cancer Inhibitor
Formula	C₈₁H₁₁₀N₂₀O₁₂
Molecular Weight	1555.87

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.