Fig. 1 · Structure
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D-Histidine hydrochloride hydrate
Anti-biofilm Agent
D-Histidine hydrochloride hydrate is an anti-biofilm agent that targets bacterial quorum sensing systems, specifically the RhlI/RhlR pathway. This compound exhibits antibacterial activity by non-covalently binding to bacterial regulatory factors, thereby selectively inhibiting biofilm formation and bacterial motility. It downregulates the expression of quorum sensing-related genes and reduces the synthesis of virulence factors, which diminishes biofilm stability and enhances antibiotic sensitivity. Additionally, D-Histidine hydrochloride hydrate acts as an effective catalyst in salt-induced peptide formation, facilitating the condensation of amino acids into dipeptides through interaction with copper ions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 328526-86-9 |
| Applications | Anti-biofilm Agent |
| Formula | C6H12ClN3O3 |
| Molecular Weight | 209.63 |
| SMILES | C([C@H](C(O)=O)N)C1=CN=CN1.Cl.O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.