Fig. 1 · Structure
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D-Isoleucine
Isoleucine Stereoisomer
D-Isoleucine is a selective competitive activator of the Asc-1 antiporter, exhibiting a Ki value of 0.98 mM. By binding to the Asc-1 protein on neuronal cell membranes, D-Isoleucine facilitates the release of D-serine and glycine, thereby enhancing NMDA receptor-dependent synaptic plasticity. This compound is relevant in the study of neurodegenerative diseases, including Alzheimer's disease and schizophrenia. Additionally, D-Isoleucine serves as a non-classical D-amino acid, disrupting bacterial peptidoglycan synthesis and inhibiting biofilm formation in Staphylococcus aureus, suggesting its potential utility in antibacterial research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 319-78-8 |
| Applications | Isoleucine Stereoisomer |
| Formula | C6H13NO2 |
| Molecular Weight | 131.18 |
| Synonyms | (R)-Isoleucine |
| SMILES | CC[C@@H](C)[C@@H](N)C(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.