Fig. 1 · Structure
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D-p-Cl-Phe6,Leu17-VIP
VIP Antagonist
[D-p-Cl-Phe6,Leu17]-VIP is a selective antagonist of the vasoactive intestinal peptide (VIP) receptor, exhibiting a competitive inhibition profile with an IC50 value of 125.8 nM. This compound demonstrates specificity, having no significant interaction with glucagon, secretin, or growth hormone-releasing factor (GRF) receptors. Its research applications include studying the role of VIP in various physiological and pathological processes, making it a valuable tool for exploring therapeutic targets related to VIP signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 102805-45-8 |
| Applications | VIP Antagonist |
| Formula | C148H239ClN44O42 |
| Molecular Weight | 3342.20 |
| SMILES | [C@@H](CC1=CC=C(O)C=C1)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](CC3=CC=C(Cl)C=C3)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC4=CN=CN4)N)=O)CO)=O)CC(O)=O)=O)C)=O)C(C)C)=O)=O)[C@@H](C)O)=O)CC(O)=O)=O)CC(N)=O)=O)=O)[C@@H](C)O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCCNC(=N)N)=O)CCCCN)=O)CCC(N)=O)=O)CC(C)C)=O)C)=O)C(C)C)=O)CCCCN)=O)CCCCN)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(N)=O)C(N)=O)=O)CC(C)C)=O)[C@H](CC)C)=O)CO)=O)CC(N)=O)=O)CC(C)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.