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D156844

SMN2 Promoter Activator

D156844 is a potent SMN2 promoter activator with an EC50 of 4 nM. This compound enhances mRNA expression of the mouse SMN in NSC-34 cells and increases the transcription of the human SMN2 promoter in fibroblasts from patients with severe type I spinal muscular atrophy (SMA). Additionally, D156844 effectively facilitates the production of full-length human SMN protein and can overcome DHFR inhibition. It is a valuable tool for research into spinal muscular atrophy and therapeutic strategies targeting SMN expression.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Activator
CAS Number	1005501-84-7
Applications	SMN2 Promoter Activator
Formula	C₂₁H₂₄FN₅O
Molecular Weight	381.45
SMILES	NC1=NC(N)=C2C(OCC3CCN(CC4=CC=CC=C4F)CC3)=CC=CC2=N1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.