DA-6886 monohydrochloride is a selective agonist of the 5-Hydroxytryptamine receptor 4 (5-HT4), demonstrated to induce relaxation in rat esophageal tissue via a 5-HT4 receptor antagonist-sensitive mechanism. This compound shows significant selectivity, with an inhibitory pIC50 value of 4.3 for hERG channels, indicating it is 1000-fold more preferential for 5-HT4 receptors. DA-6886 is suitable for research into constipated irritable bowel syndrome and related gastrointestinal disorders.
DA-6886 monohydrochloride is a selective agonist of the 5-Hydroxytryptamine receptor 4 (5-HT4), demonstrated to induce relaxation in rat esophageal tissue via a 5-HT4 receptor antagonist-sensitive mechanism. This compound shows significant selectivity, with an inhibitory pIC50 value of 4.3 for hERG channels, indicating it is 1000-fold more preferential for 5-HT4 receptors. DA-6886 is suitable for research into constipated irritable bowel syndrome and related gastrointestinal disorders.
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