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DAM-001

hDAT Allosteric Inhibitor

DAM-001 is a potent allosteric inhibitor of the human dopamine transporter (hDAT), exhibiting an IC50 of 24.70 μM in the absence of orthosteric inhibitors and 1.026 μM in the presence of Nomifensine. This compound can be utilized in research focused on the modulation of dopamine transport, making it relevant for studies related to neuropharmacology and the pathophysiology of neuropsychiatric disorders. Its ability to affect hDAT activity enhances its potential for investigating therapeutic strategies targeting dopamine-mediated signaling pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1090396-31-8
Applications	hDAT Allosteric Inhibitor
Formula	C₁₈H₂₃N₃O
Molecular Weight	297.39
Synonyms	Z236004662
SMILES	O=C(C1CCCC1)N(CCC2)CC2C3=NC4=CC=CC=C4N3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.