Fig. 1 · Structure
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Danazol
Synthetic Steroid
Danazol is a synthetic steroid that primarily inhibits the proliferation of cancer cells, specifically MDA-MB-231 and MCF-7, with IC50 values of 65 µg/mL and 31 µg/mL, respectively. It effectively arrests the cell cycle at the G1 phase and induces apoptosis in MDA-MB-231 cells via the PKCα signaling pathway. This compound is valuable for research on breast cancer biology and therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 17230-88-5 |
| Applications | Synthetic Steroid |
| Formula | C22H27NO2 |
| Molecular Weight | 337.46 |
| SMILES | C#C[C@]1(O)CC[C@@]2([H])[C@]3([H])CCC4=CC5=C(C=NO5)C[C@]4(C)[C@@]3([H])CC[C@@]21C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.