Fig. 1 · Structure
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Dasatinib-d8
Stable Isotope
Dasatinib-d8 is a deuterium-labeled analog of Dasatinib, a dual inhibitor of Bcr-Abl and Src family tyrosine kinases. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research, allowing for precise measurement of drug disposition and biological effects. Its application facilitates investigations into the mechanisms of action and resistance patterns associated with tyrosine kinase inhibitors in cancer therapy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1132093-70-9 |
| Applications | Stable Isotope |
| Formula | C22H18D8ClN7O2S |
| Molecular Weight | 496.05 |
| Synonyms | BMS-354825-d8 |
| SMILES | O=C(C1=CN=C(NC2=NC(C)=NC(N3C([2H])([2H])C([2H])([2H])N(CCO)C([2H])([2H])C3([2H])[2H])=C2)S1)NC4=C(C)C=CC=C4Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.