Fig. 1 · Structure
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Dasatinib N-oxide
Dasatinib Metabolite
Dasatinib N-oxide is a minor metabolite of Dasatinib, which functions primarily as a potent and orally bioavailable dual inhibitor of Src and Bcr-Abl kinases. This compound plays a significant role in the pharmacokinetics and metabolism of Dasatinib, contributing to understanding its therapeutic effects and potential side effects. Researchers can utilize Dasatinib N-oxide to study its biological activity and implications in cancer treatment, particularly in relation to chronic myeloid leukemia and other Src-related malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 910297-52-8 |
| Applications | Dasatinib Metabolite |
| Formula | C22H26ClN7O3S |
| Molecular Weight | 504.00 |
| SMILES | O=C(C1=CN=C(NC2=NC(C)=NC(N3CC[N+](CCO)([O-])CC3)=C2)S1)NC4=C(C)C=CC=C4Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.