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dAURK-4

PROTAC AURKA Degrader

dAURK-4 is a potent and selective degrader of Aurora A kinase (AURKA) utilizing the PROTAC (proteolysis-targeting chimera) approach. This compound induces the degradation of AURKA, leading to significant antitumor activity. dAURK-4 is ideal for research applications focused on cancer biology, particularly in studies exploring the role of AURKA in tumorigenesis and therapeutic resistance.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2705844-81-9
Applications	PROTAC AURKA Degrader
Formula	C₅₂H₅₂ClFN₈O₁₂
Molecular Weight	1035.47
SMILES	O=C(N(C1C(NC(CC1)=O)=O)C2=O)C3=C2C=CC=C3OCC(NCCCOCCOCCOCCCNC(C4=CC=C(NC5=NC=C6C(C(C=CC(Cl)=C7)=C7C(C8=C(F)C=CC=C8OC)=NC6)=N5)C=C4OC)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.