Fig. 1 · Structure
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DB18
CLK Inhibitor
DB18 is a potent and selective inhibitor of CDC2-like kinases (CLKs), demonstrating IC50 values between 10-30 nM for CLK1, CLK2, and CLK4. This compound exhibits anti-tumor activity, making it valuable for research applications aimed at understanding cancer biology and therapeutic interventions targeting CLK-mediated signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2587177-94-2 |
| Applications | CLK Inhibitor |
| Formula | C24H18ClN7O3 |
| Molecular Weight | 487.90 |
| SMILES | CC1=CC=C(C([N+]([O-])=O)=C1)N2C=C(N=N2)COC3=CC=CC4=C3N=C(N=C4)NC5=CC=CC(Cl)=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.