DB1976 is a potent PU.1 inhibitor, functioning through the disruption of PU.1 binding to DNA. With an IC50 of 10 nM, it effectively prevents the formation of the PU.1/DNA complex, exhibiting a high affinity (KD of 12 nM) in vitro. This compound demonstrates the ability to induce apoptosis, making it a valuable tool for research applications targeting transcriptional regulation and cellular apoptosis pathways.
DB1976 is a potent PU.1 inhibitor, functioning through the disruption of PU.1 binding to DNA. With an IC50 of 10 nM, it effectively prevents the formation of the PU.1/DNA complex, exhibiting a high affinity (KD of 12 nM) in vitro. This compound demonstrates the ability to induce apoptosis, making it a valuable tool for research applications targeting transcriptional regulation and cellular apoptosis pathways.
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