Fig. 1 · Structure
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DB1976
PU.1 Inhibitor
DB1976 is a potent PU.1 inhibitor, functioning through the disruption of PU.1 binding to DNA. With an IC50 of 10 nM, it effectively prevents the formation of the PU.1/DNA complex, exhibiting a high affinity (KD of 12 nM) in vitro. This compound demonstrates the ability to induce apoptosis, making it a valuable tool for research applications targeting transcriptional regulation and cellular apoptosis pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1557397-51-9 |
| Applications | PU.1 Inhibitor |
| Formula | C20H16N8Se |
| Molecular Weight | 447.35 |
| SMILES | N=C(C1=CC=C2N=C(C3=CC=C(C4=NC5=CC=C(C(N)=N)C=C5N4)[Se]3)NC2=C1)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.