Fig. 1 · Structure
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DB2115 tertahydrochloride
PU. 1 Inhibitor
DB2115 tetrahydrochloride is a highly selective inhibitor of the transcription factor PU.1, demonstrating an IC50 of 2.3 nM in blocking PU.1's binding to DNA. This compound effectively inhibits tumor cell proliferation and induces apoptosis in various cancer cell lines. DB2115 tetrahydrochloride is valuable for investigating tumor biology, particularly in the context of leukemia research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1366126-19-3 |
| Applications | PU. 1 Inhibitor |
| Formula | C32H34Cl4N8O2 |
| Molecular Weight | 704.48 |
| SMILES | N=C(C1=CC=C2N=C(C3=CC=C(OCCCCOC4=CC=C(C5=NC6=CC=C(C(N)=N)C=C6N5)C=C4)C=C3)NC2=C1)N.[H]Cl.[H]Cl.[H]Cl.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.