Fig. 1 · Structure
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DC-5163
GAPDH Inhibitor
DC-5163 is a potent inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), demonstrating an IC50 value of 176.3 nM and a Kd of 3.192 μM. This compound partially disrupts the glycolytic pathway, leading to selective inhibition of cancer cell proliferation and the induction of apoptosis. It serves as a valuable reagent for research into cancer metabolism and therapeutic strategies targeting glycolysis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 897771-47-0 |
| Applications | GAPDH Inhibitor |
| Formula | C18H20ClN3OS |
| Molecular Weight | 361.89 |
| SMILES | S=C(N1CCN(CC2=CC=CC=C2)C1)NC3=CC=C(OC)C(Cl)=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.