Documents & Downloads

DC-PGKI

PGK1 Inhibitor

DC-PGKI is an orally active ATP-competitive inhibitor of phosphoglycerate kinase 1 (PGK1) with an IC50 of 0.16 µM and a Kd of 99.08 nM. This compound effectively stabilizes PGK1 both in vitro and in vivo, resulting in the suppression of glycolytic activity and kinase function. Inhibition of PGK1 by DC-PGKI promotes the accumulation of NRF2, facilitating its translocation to the nucleus where it represses the LPS-induced expression of IL-1β and IL-6 genes. DC-PGKI is a valuable tool for investigating colitis and related inflammatory pathways.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2829198-49-2
Applications	PGK1 Inhibitor
Formula	C₂₆H₂₉Cl₂N₇O₃
Molecular Weight	558.46
SMILES	O=C(N1CCN(C2=NC3=C(N=C2C(OCC)=O)C=C(Cl)C(Cl)=C3)CC1)NC(C=C4)=CC=C4N5CCNCC5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.