Fig. 1 · Structure
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DC-U4106
USP8-targeting Inhibitor
DC-U4106 is a selective inhibitor of the deubiquitinating enzyme USP8, exhibiting a Kd value of 4.7 μM and an IC50 of 1.2 μM. By targeting the ubiquitin pathway, DC-U4106 promotes the degradation of the estrogen receptor alpha (Erα), thereby inhibiting tumorigenesis. This compound demonstrates minimal toxicity and shows promise in breast cancer research applications, making it a valuable tool for exploring the therapeutic effects of USP8 inhibition in cancer biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2410534-62-0 |
| Applications | USP8-targeting Inhibitor |
| Formula | C29H27N5O5 |
| Molecular Weight | 525.56 |
| SMILES | O=C1C=C(C2=CC=C(N3CCN(C4=NC=CC=C4)CC3)C=C2)OC5=C1C(O)=CC(O)=C5OC6=C(C)NN=C6C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.